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J.KangA.et al (2016)

44, S110S114

Common symptoms include fatigue, weakness, memory problems, difficulty concentrating, tingling sensations in the hands and feet, and mood changes

The compound 37 connected through an ether linkage show 713-fold decrease in the inhibitory ability (IC 50 = 378.11 M) indicate the sulfur atom is very important in chelating with the copper ions and contributes in a greater inhibition tyrosinase activity

The complexity of their subunit composition 25 leads to highly diverse functional and pharmacological properties, enabling the sensitive regulation of synaptic transmission 2,27,28,29,30,31,32,33,34,35,36