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doi: 10.3389/fnut.2024.1266690 Received 25 July 2023 Accepted 29 January 2024 Published 21 February 2024 Volume 11 - 2024 Edited by Sunmin Park, Hoseo University, Republic of Korea Reviewed by Zhenwei Cui, Zhengzhou University, China Sergei V

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In acid sphingomyelinase knock-out mice, which mimic a neurovisceral acid sphingomyelinase deficiency (ASMD) characterized by cellular accumulation of sphingomyelin, the effects of a choline-free diet decreased the activation of liver macrophages and microglia, but it did not significantly alter sphingomyelin levels due to compensatory mechanisms involving methionine metabolism (101)

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