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The observation that replacement of the N-terminal norleucine with GABA yielded a compound with superior antidementia activity indicated that an N-terminal -amino group was not required for activity

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Hydration also plays a significant role

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Epilepsy Epilepsy is characterized by sudden, temporary synchronization of electrical charges in groups of neurons, which may manifest as seizures

Studies have shown that CD22 is abnormally overexpressed in aged microglia, which is closely associated with reduced phagocytic clearance of A, increased release of inflammatory cytokines, and activation of the complement system [103]