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Of note, it remains speculative as to how pineal-produced and gut-derived melatonin interrelate, whether there is any gut-pineal axis crosstalk, and how different dietary patterns or even specific foods, fasting regimens, or timing of meals (chrononutrition) may alter systemic melatonin levels or the physiological relevance of any changes

Introduction Neurodegenerative diseases (NDs) are the prominent source of disability and cause approximately 12% of all deaths at the global level

doi: 10.1016/j.chemosphere.2019.125350 [DOI] [PubMed] [Google Scholar] Sofo A., Moreira I., Gattullo C

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# Some reactive irritants as mustard oil can form transient or permanent covalent bonds with the channel, activating it