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It was observed that the commercial production step resulting in the greatest folate loss was the holding of hot, freshly ground, fortified masa (for 0.54 h) before baking

2012), copper chloride (Scheiber and Dringen 2011

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Other indications include malabsorption disorders (such as Crohn's disease or coeliac disease), following gastric surgery, strict vegan diets without supplementation, and certain medications that interfere with B12 absorption