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doi: 10.1056/NEJMoa072200

showed that cholesterol crystals serve as DAMPs and cause the activation of the NLRP3 [nucleotide-binding domain leucine-rich repeat containing (NLR) family, pyrin domain containing 3] inflammasome in macrophages (Rajamaki et al., 2010)

Free Radic Biol Med, 1999

Simtuzumab as antifibrotic strategy Simtuzumab is a humanised monoclonal antibody against lysyl oxidase-like 2 (LOXL2), which has raised much hope for treatment of fibrosis in both NASH and PSC, since LOXL2 contributes to fibrogenesis by cross-linkage of collagen and regulates bile duct permeability.225 226 In patients with PSC and NASH increased serum levels of LOXL2 correlate with more advanced fibrosis and severity of portal hypertension.226 227 Despite these encouraging findings, simtuzumab failed to show antifibrotic effects in NASH patients with bridging fibrosis or compensated cirrhosis227 and in patients with PSC228 (table 1)

Vitamin C is a vital nutrient involved in hundreds of processes throughout the body, from collagen production and immune defence to iron absorption and antioxidant protection