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In particular, the difference between the two groups' intake of vitamin B12 was described as 'highly significant'

Warning: Supplementing with folate, even in some cases of high dietary folate intake, prevents or masks this folate trap process, but it does not remedy B12 deficiency or homocysteine accumulation (although it is possible that the latter may appear somewhat lower in the analysis than if you were not taking a diet high in folate, as folate is a cofactor that lowers homocysteine

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Clues to an attack of gout coming on include local swelling, heat, redness, and tenderness in a joint, especially in the foot, ankle, or knee

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Recheck Homocysteine along with Vitamin B12, Folate, and Methylmalonic Acid to confirm response