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Description
Clinical trials represent the most resource-intensive and failure-prone phase of drug R&Dand are even more complex in the context of rare diseases (Table 1)

Vidovic M, Rikalovic MG

2007), and 5-hydroxymethylfurfural oxidase (Dijkman & Fraaije 2014)

Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
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On the biological level, changes in fluid biomarkers, inflammatory markers, SCFA levels, and intestinal permeability markers can offer mechanistic insights and contribute to elucidating pathophysiology (16, 20)
