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Here, we show that pharmacological or genetic CoQ deficiency in BAT leads to stress signals causing accumulation of cytosolic mitochondrial RNAs and activation of the eIF2 kinase PKR, resulting in activation of the integrated stress response (ISR) with suppression of UCP1 but induction of FGF21 expression

Difficulties in replicating findings is unfortunately the case of many MRS studies, in both ME/CFS and other conditions

Casas H, Murtra B, Casas M, Ibanez J, Ventura JL, Ricart A, Rodriguez F, Viscor G, Palacios L, Pages T, Rama R: Increased blood ammonia in hypoxia during exercise in humans

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Additionally, when directed toward mitochondria and betaine synthesis, choline serves as a methyl donor for histone and protein methylation, key processes that regulate gene expression and cellular activity