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Activation of the ARE is a defense mechanism that is designed to protect cells against oxidative damage and this inadvertently attenuates one the therapeutic effects of tamoxifen and decreases its efficacy

Furthermore, it has been observed that the patterns of histone modifications are closely associated with the expression levels of various drug transporters, including ABCB1 (MDR1) and ABCG2 (BCRP) [102]
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Second-line therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a systematic review and mixed-treatment comparison meta-analysis

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