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Obesity-related steatosis, or NAFLD in particular, is a major public health concern worldwide and is frequently associated with insulin resistance and type 2 diabetes mellitus

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These include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative mortality, inducing or accessing vasculature, activating invasion and metastasis, deregulating cellular metabolism, avoiding immune destruction, genome instability and mutation, tumor-promoting inflammation, unlocking phenotypic plasticity, nonmutational epigenetic reprogramming, polymorphic microbiomes, and senescent cells [2]

Int J Cancer (2004) 108(2):1818

doi:10.1023/a:1008049117811 31

Lykotrafitis, S