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Preclinical studies in flies demonstrated that supplementation with NR or NMN improved mitochondrial respiration and membrane potential, and exercise endurance was improved 304,305
This means it can normalize nitric oxide levels whether they are too high or too low
Ann Nutr Metab

Retrieved from Kupila SKE, Joki A, Suojanen LU, Pietilinen KH
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It might lead to scarring, compromised vascular supply, and impaired cell niches necessary to support sperm or follicles
