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A total of 83.1% of investigators and 84.2% of patients reported clinical efficacy, which was excellent in almost one-third of patients

It is known that TBK1 phosphorylates serine residues near the LIR of ubiquitin-binding adapter proteins, including OPTN, to enhance binding affinity toward LC3 via conformational alteration and subsequent avidity effect 29

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CoQ molecules are dynamically divided in a pool attached to and engulfed by the super-complexes I + III, and another pool related to complex II or other mitochondrial enzymes using CoQ as a cofactor

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