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As therapies targeting ferroptosis are developed, tracking the effects of treatments on MDA and GPX4 levels could provide valuable insights into the degree of ferroptosis inhibition achieved and its resultant influence on inflammation and tissue damage

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This regulation led to altered expression of key autophagy-related proteins (upregulated LC3/Beclin-1, downregulated p62) and apoptosis-related proteins (increased Bcl-2/Bax ratio, reduced Caspase-3/7 levels) (130)

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Purpose To investigate the integrated therapeutic benefits of the phytopharmaceutical berberine and mucoadhesive nanoliposomes, administered via the nose-to-brain route, to enhance bioavailability, facilitate blood-brain barrier penetration, and augment efficacy against neurodegenerative progression in Parkinsons disease (PD)