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Although we performed multivariate adjustments, residual confounding may persist due to unmeasured factors such as dietary habits (e.g., irregular intake of animal-derived foods or B12-fortified products), unrecorded use of nutritional supplements, and genetic predispositionsparticularly MTHFR polymorphisms, which are known to influence homocysteine metabolism and folate cycling, thereby potentially altering the functional demand for vitamin B12

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Destruction of these cells curtails the production of intrinsic factor and subsequently limits vitamin B 12 absorption

Since these therapies are standard treatments for many cancers, the development of most cancer vaccines will involve patients who have already received or are undergoing these treatments