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A similar effect is achieved by increasing the insulin receptor sensitivity, which may be the basis for treating insulin resistance because, this way, a larger amount of glucose could enter the cells and be converted into energy

Turkish Journal of Medical Sciences

Thorax 2011;66:3205

Unfortunately, the same chemical property that enhances bioavailability of drugs may also make renal excretion difficult, because clearance by the kidney requires that these drugs be made more hydrophilic so that they can dissolve in the aqueous urine

10.1038/ncomms11934 140 IulianoE.di CagnoA.AquinoG.FiorilliG.MignognaP.CalcagnoG.et al (2015)

Transcriptional profiling of lung macrophages following ozone exposure in mice identifies signaling pathways regulating immunometabolic activation