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The two are paired because they work on different scales : BPC-157 acts locally at the site of injury, while TB-500 works systemically across the whole body
383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)
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