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the majority circulates in a large, roughly 150-kDa ternary complex composed of IGF-1, IGFBP-3 (or IGFBP-5), and a third protein called the acid-labile subunit (ALS)

Medical Applications: Patients with Crohns disease, celiac disease, or gastric bypass surgery achieve therapeutic nutrient levels impossible through oral supplementation

Some individuals use this combination with the aim of supporting physical performance or weight management, though clinical evidence supporting such benefits remains limited

Boysen G, Kenney PM, Upadhyaya P, Wang M, Hecht SS

10.1113/EP092036 50 FaridvandY.KazemzadehH.VahedianV.MirzajanzadehP.NejabatiH

doi: 10.1021/jo011172x