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doi: 10.1007/s40472-020-00302-1 Summary Keywords ischemia-reperfusion injury (IRI), vascularized composite allotransplantation (VCA), tissue damage, transplant rejection, innate immunity, adaptive immunity Citation He J, Khan UZ, Qing L, Wu P and Tang J (2022) Improving the ischemia-reperfusion injury in vascularized composite allotransplantation: Clinical experience and experimental implications