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99 In HEK293 cells, Co-IP assay results revealed that SCF TrCP -E3 ligase and DYRK1A could be precipitated simultaneously by TrCP antibody while knockdown of TrCP expression with siRNA significantly increased DRYK1A protein levels, indicating that SCF TrCP -mediated ubiquitination and promoted degradation of DYRK1A, 100 adding to the role of the UPS in influencing APP processing
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Hu Y, Zhang Z, Li Y, et al
