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The tradeoff is larger injection volumes at higher doses

One 2023 systematic review discovered that there was a 2.4 times increased risk of insomnia symptoms with low vitamin B12 levels, with the association more significant in the non-obese, older adults and women

In addition to helping your cells produce energy, vitamin B12 plays a key role in brain health, DNA synthesis, red blood cell formation and the production of serotonin and dopamine two neurotransmitters that support focus and mood

If that is the case, a Vitamin B12 injection can help

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Theoretically this interaction is possible with other proton pump inhibitors (PPIs), although specific clinical data are lacking