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Knockout of GPT2 inhibits CSE-induced PC and TAG abnormalities, alleviating lung damage

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15 , eadg8464 (2023)

Introduction Copper (Cu) is a ubiquitous trace element stored primarily in the liver, but also present in other organs, such as the brain, heart, kidney, and muscles (Osredkar and Sustar, in vivo regulation of copper levels in biological systems is under strict control through the actions of copper transporters and chaperones (Harris, Defects in the ATP7B gene encoding a copper transporting Cu-ATPase disrupt the homeostatic copper balance leading to Wilson disease (WD), that is characterized by reduced biliary Cu excretion, and impaired Cu incorporation into Cp (Cox and Moore, D-Penicillamine (PA) (Figure 1A), first identified as a product of penicillin hydrolysis, is the drug of choice to treat WD patients, is marketed as Cuprimine or Depen (Stephenson and Roberson, 2 ) groups forming a non-toxic ring complex (Figure 1B