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Figure 5 In addition, ATP serves as a neurotransmitter, co-transmitter, and neuromodulator, undertaking an important role in pain processing, and ATP P1 receptors (A1, A2A, A2B, and A3) are found ubiquitously expressed in the nervous system (Franco et al., 2021)

The exact mechanisms of communication between adipocytes and tumor cells are not completely understood

Inflammation : Chronic inflammation or joint discomfort

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This is a narrative review and a bibliographical survey of articles in the databases PubMed and Science Direct without limit for the year of publication, selected from August to September 2016