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(2017) 356:eaaj2239

Some cytosolic GSH is transported, thanks to a specific transporter, the multidrug resistance protein 1 (MRP1), out of the cell to maintain a balance in the redox level [22], or can be conjugated by GSH transferases (GST) with endogenous metabolites, such as cysteinyl leukotriene or xenobiotics (therapeutics, anticancer drugs, carcinogens, pesticides, herbicides), forming a complex GSH-Xen, which is transported outside the cell by MRP1 [19]

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Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial

In some cases, the necessary preparation imposes a stress on the sample, which could modify the factor being measured
