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In contrast, the M105I mutant maintains the hydrophobic loop (F27/F28 residues) in a consistently buried state throughout the simulations, failing to adopt the extended loop conformation characteristic of the WT structure

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doi: 10.1016/j.ejphar.2011.05.075

The IGF Axis and Its Role in Tumor Biology IGF: Dramatis Moleculae Insulin-like growth factor (IGF) signaling plays an important role in regulating growth and development in normal human tissues by promoting cellular proliferation and differentiation and preventing apoptosis [1, 2]

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Temporal profiles of the levels of endogenous antioxidants after four-vessel occlusion in rats