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Ping Zhou, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In addition, the tests of teratogenicity and genotoxicity (Salmonella microsome test) proved no signs of such action

Mechanism of PRP in Osteoarthritis PRP contains growth factors and cytokines that promote cartilage repair and modulate inflammation, including: Platelet-derived growth factor (PDGF): Stimulates chondrocyte proliferation and matrix synthesis Transforming growth factor-beta (TGF-): Encourages cartilage regeneration and reduces catabolic activity Vascular endothelial growth factor (VEGF): Enhances microcirculation to support healing Interleukin-1 receptor antagonist (IL-1Ra): Suppresses pro-inflammatory cytokines that degrade cartilage These biological effects differentiate PRP from corticosteroids , which primarily suppress symptoms but accelerate cartilage degradation with repeated use (PMID: 30404447)

Chen, Thomas C.Neuro-Oncology (Cary, NC, United States) (2021), 23 (10), 1656-1667CODEN: NEURJR
Because B12 is primarily found in animal-based products, vegetarians and vegans are particularly susceptible to B12 deficiencies

Mol Oncol
