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Meulener, M

Depression is frequently accompanied by inflammation, and microglia are essential starting materials and controllers of the cynaroside (CNS) inflammatory cascade responses (Wang H

Ross D, Siegel D

Inhibiting this cytokine classically leads to the reactivation of latent granulomatous infections, most notably tuberculosis, and invasive fungal infections

Additionally, cost-effectiveness, clinical feasibility, and the durability of long-term effects are also critical issues that future research needs to address

Activated p53 triggers cell cycle arrest to provide damaged DNA with enough time to repair or, in the case of excessive damage, to initiate apoptosis, thus preventing the proliferation of cells carrying severe genetic defects (42, 43)