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The general form, applicable to all the different metalcoordinated forms of SOD, can be written as follows: M (n+1)+ SOD + O 2 M n+ SOD + O 2 M n+ SOD + O 2 + 2H + M (n+1)+ SOD + H 2 O 2 The reactions by which SODcatalyzed dismutation of superoxide for Cu,Zn SOD can be written as follows: Cu 2+ SOD + O 2 Cu + SOD + O 2 (reduction of copper

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The evaluated biosafety results of nanomaterials are always obtained based on the in vitro or in vivo animal study

doi: 10.1016/j.celrep.2017.04.039

Sangsu Bang, Duke University, USA Updates Copyright 2017 Chan, Saad, Al-Odat, Oliver, Pollock, Jones and Chen

2 However, the SC route is also known and described to be associated with some discomfort and local pain which altogether can compromise patients adherence to treatment