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Subject terms: Biochemistry, Cell biology, Metabolic disorders Introduction Nicotinamide adenine dinucleotide (NAD + ) is an essential redox coenzyme that exists between the oxidized form NAD + and its reduced form (NADH) 1

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294 Under normal conditions, Trx binds to the N-terminal region of the apoptosis signal-regulating kinase 1 (ASK1)