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above approximately pH 7.4 the Cu(II) chelate begins to release copper and the solution darkens

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well-tolerated in mice, rats, rabbits, and dogs with no serious organ toxicity.[34][35] Clinical Safety : Mild local irritation possible at injection sites, but no systemic adverse effects reported in trials.[36][37] Potential Risks : Theoretical concerns include pro-angiogenic effects potentially promoting tumor growth, though no evidence supports this in studies.[38] Long-term human data is limited, so monitoring is advised

Although ACD is not the result of iron deficiency (iron stores are not depleted), it is associated with disturbance of iron metabolism that is reflected in blood test results

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