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Zesiewicz et al., 2018)

Choose products with lower sugar content and reduce the consumption of products with added sugars

Concurrently, the focal adhesion pathway was hyperactivated, as evidenced by the upregulated expression of key adhesion and cytoskeletal linker proteins, including Actn1 , Tln1 , and Rac2 (3.1- to 8.5-fold), suggesting enhanced cell-ECM adhesion signaling under HFD

nevertheless, testing should be completed on siblings of probands due to the largely unknown relationship between genotype and phenotype of MCADD, which may result in individuals remaining asymptomatic until a sudden onset later in life

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