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The major location, within the brain, for norepinephrine synthesis is the locus coeruleus of the brainstem

Biology Methods and Protocols, 9, bpae015

[DOI] [PubMed] [Google Scholar] [129].Tran TV, Shin EJ, Nguyen LTT, Lee Y, Kim DJ, Jeong JH, Jang CG, Nah SY, Toriumi K, Nabeshima T, Yamada K, Kim HC, Protein kinase Cdelta gene depletion protects against methamphetamine-induced impairments in recognition memory and ERK1/2 signaling via upregulation of glutathione peroxidase-1 gene

Your cells wont have as much protection from damage, which can affect how efficiently they produce energy

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