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doi: 10.1007/s11051-022-05469-5

This depends on the treatment

Vitamin B12 is water soluble, so it is a very safe medication

G6PD-deficient cells are unable to generate enough NADPH under the condition of severe thiol depletion and GSH biosynthesis and methionine cycle are upregulated at the expense of ATP but fail to compensate for GSH depletion (311)

While existing trials are focusing on repurposed agents such as the diuretic bumetanide, the vasopressin 1a receptor agonist, balovaptan and the GABA B receptor agonist, baclofen, modulation of histamine receptors may be an additional viable target in helping to ameliorate difficulties associated with NDDs

doi: 10.3233/jad-2006-9405 127 LeiPAytonSFinkelsteinDISpoerriLCiccotostoGDWrightDKet al