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Clinical outcome association analyses To determine whether improvements across clinical symptom domains (urinary, gait, cognitive) were interrelated following shunt surgery, each domain was binarized as improved or not improved according to predefined clinical criteria

MINOR CLARIFICATIONS S0

PRPs Role in Cartilage Preservation and Disease Modification Unlike traditional treatments that primarily suppress symptoms , PRP has shown potential to slow OA progression and enhance cartilage repair : A study using MRI imaging found that patients receiving PRP had higher cartilage thickness and lower cartilage degeneration scores compared to those receiving HA (PMID: 35188121)

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On day 2, the patient revealed using approximately 500 mL of room temperature coffee enema several hours before the onset of her symptoms

Mechanism: Benzyl Alcohol serves two functions