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Psychological stress is linked to elevated OS in both animal and human models and has been widely reported (138)
doi: 10.1002/adfm.202105152
Cellular redox imbalance, driven by excessive ROS, disrupts thiol homeostasis by oxidizing critical cysteine residues in proteins (e.g., caspases, BAX and GPX4) and small molecules such as GSH (30)
M., Rahman, G
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For example, zinc ions may be able to bind to specific cysteine-rich regions in TRAF2, which contain zinc-binding motifs
