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Topical therapies were not working either
doi:10.1074/jbc.270.13.7176
doi: 10.1007/s00344-012-9273-9

Curr Neuropharmacol 2016

and Tittmann K

There are two states of glutathione in the cells: reduced glutathione (GSH) and oxidized glutathione disulfide (GSSG)
