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Conversely, downregulated genes were enriched for cellcell adhesion, indicating disrupted structural connectivity

Preclinical studies have shown that FLASH-RT reduces radiation-induced damage to normal tissues, such as the lungs, gastrointestinal tract, and skin, by protecting these tissues from inflammation and fibrosis

In severe COVID-19 or acute respiratory distress syndrome (ARDS), an mRNA therapy delivered to the lung could, in theory, provide a therapeutic protein (for example, an anti-inflammatory cytokine or a soluble receptor to neutralize inflammatory signals) right at the site of injury

To further determine whether Rv0801mediated survival involves perturbing this balance, we pre-treated THP1 macrophages with the ROS inhibitor Nacetylcysteine (NAC, 2 mM) for 18 h ( Figure 4C ) or exogenously supplemented with 0.1 mM GSH after 4 h infection

Overall, while glutathione is generally safe, it should be taken with medical advice in these populations to avoid adverse interactions and ensure safety

This chapter discusses the characteristic features of glutamine metabolism in cancers and the therapeutic options to target glutamine metabolism for cancer treatment