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Reducing UA levels in the body by inhibiting the activity of XOD is currently the main treating method, commonly use drugs such as allopurinol, febuxostat, and topiroxostat

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These reflect the guiding principles in Japan as a pioneer of the global less is more trend, while acknowledging that conventional comprehensive treatment (total thyroidectomy, lymph node dissection, RAI therapy, and TSH suppression) for high-risk PTC may not be fully validated (Column 2-2)

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