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[PubMed: 11196460] 33

10.1016/j.parint.2020.102224

Keap1 facilitates redox-sensitive regulation of kinase activation by serving as a scaffold for upstream MAPK regulators, including PGAM5, and Ikk Keap1s function as a substrate adapter for cullin-3 E3 ligase enables it to target MAPK pathway components for ubiquitination and destruction, whereas oxidative alteration of its cysteine residue can change these proteinprotein interactions [91]

Smoking drains glutathione reserves rapidly

In addition, increased intake of BCAAs is associated with a decrease in inflammation, as indicated by reduced hs-CRP levels (122)

PubMed Scholar Freson K, Devriendt K, Matthijs G
