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Importantly, persistent activation of NRF2 that is induced pharmacologically in KEAP1-NRF2-intact cancer cells also decreases NEAA synthesis and makes them rely on exogenous NEAAs (LeBoeuf et al

The numbers of ligand or chelating agents are affecting the stability of metal complexes so as these numbers go up and down, the stability will also vary with it

Zhang H, Wang Y, Wang S, et al

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By substituting different functional groups, they found that compound 51 with methylcytosine had better activity and exerted its antioxidant capacity mainly by trapping free radicals, thus protecting against elastin-induced cellular ferroptosis

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