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Abstract Deoxynivalenol (DON) is a prevalent foodborne mycotoxin severely compromising livestock and poultry health and food safety

We have previously shown that the cell death associated with lysosomotropic compounds can be rescued by Bafilomycin A, which increases lysosomal pH and prevents compound accumulation, further supporting lysosomal accumulation as the cause for cell death [54]

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For instance, an increased p-S6 expression in Tregs has been observed under inflammatory conditions, in tumor microenvironments, and during autoimmune disease progression, often coinciding with diminished FOXP3 expression and acquisition of effector-like properties (72)