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D., Monopoli A., Ditaranto N., Palmisano F

Chikina, A

Regorafenib plus nivolumab in patients with mismatch repair-proficient/microsatellite stable metastatic colorectal cancer: a single-arm, open-label, multicentre phase 2 study

87 The existence of reversibility within DTP cells allows for a small number of cancer cells to persist in the body for an extended period through flexible transformation of the DTP cells, complementing the stemness or plasticity of these cells

In the United States, its upper limit is set at 100 mg per day (roughly 75 times the Recommended Dietary Allowance), which is based on case reports showing that reversible sensory neuropathy occurs after long-term use of doses exceeding 1,000 mg (78)
Selleski N, Almeida LM, Almeida FC, Gandolfi L, Pratesi R, Nobrega YKM
