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All following steps were carried out on ice or at 4 C

[25] reported that metformin can reduce the protein stability of SLC7A11 by inhibiting its UFMylation, suggesting that UFM1/SLC7A11 may be a new potential anticancer target, but the specific mechanism by which UFM1 acts on SLC7A11 remains unclear

Leukemia 23 , 21292138 (2009)

BAP1 represses SLC7A11 expression by decreasing H2Aub occupancy on the SLC7A11 promoter in many cancers (Zhang et al., 2018)

But here's the detail you should know: not having enough glutathione contributes to oxidative stress, which plays a major role in the mechanisms of complex disorders

Choice A: Decreased lung elasticity is the primary pathophysiologic mechanism of emphysema, which leads to hyperinflation and an obstructive pulmonary function pattern