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Therefore, well-designed RCTs with larger sample sizes are needed to evaluate the adjuvant role of antioxidants in combination with active treatments, especially with new biologic agents

SiNPs (S100As3.2) lessen the concentration of As in the shoot than the root, resulting in the complexation SiNPs=As(III)PCs of As, which is ultimately sequestrated within the plant vacuoles (Fig

Furthermore, in 100 PD and 50 normal subject, significant increases were noticed in the concentrations of ornithine, phenylalanine, isoleucine, -hydroxybutyric acid, tyrosine, and succinic acid detected by high-resolution nuclear magnetic resonance spectroscopy (Wang et al., 2023) (see Table 4) Table 4 Urine biomarkers in PD patients

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It is important to mention that elevated CXCL10 and HGF levels, along with decreased IL-10 protein levels, have been associated with worsening cognitive function from recruitment to the six-month follow-up in the previous study by Souza-Silva et al