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Fatigue is not only an independent disease, but also a symptom of many chronic diseases (Menting et al

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In DILI, various drug-specific signaling pathways may influence interactions between hepatocytes and immune cells

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9 Immunosenescence is also regulated by signaling pathways such as the nuclear factor-kappa B (NF-B), mTOR, JAK-STAT, melatonin, and sirtuin pathways, whose dysregulation leads to aberrant immune responses and increased susceptibility to age-related diseases
