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[DOI] [PubMed] [Google Scholar] 39.Chini EN

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Following that, the frequency changes based on your response

A general finding is that obese patients fulfilling criteria for MetS together with low IGF-1 plasma levels tend to develop a worse cardiovascular disease outcome than those with mid-normal to high-normal IGF-1 levels [213]

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While both can support weight loss, they work through different mechanisms and are used for different health goals.
