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While ovarian aging has been examined mostly in terms of the diminishing pool of available oocytes, the reduced follicular mass also produces fewer peptide hormones which may have direct implications for the endometrium

HIF-PHIs, Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors

Reduced skeletal muscle mitochondrial function in older HIV-infected men is associated with low aerobic exercise capacity

Timestamps 00:00 Cold open: 200 years of menopause medicine 03:23 Welcome and roadmap 04:20 The HPG axis, follicles, and the FSH lag 09:11 STRAW+10 staging and the timing of perimenopause 13:47 Austin: the 49-year-old with a hormone panel 20:00 Loraine: the OB-GYN workup 28:00 Symptom attribution: what menopause actually causes 33:46 Austin: the all-estrogen patient 37:58 VMS duration and the KNDy mechanism (Avis, SKYLIGHT) 43:53 Austin: who actually gets fezolinetant 47:22 The WHI 24-year correction (Manson, Chlebowski, Boardman) 01:00:15 Modern prescribing today 01:06:52 Where the menopause-content space gets it right and wrong 01:11:50 Testosterone, compounded bioidenticals, and DUTCH panels 01:24:13 Takeaways What we cover The HPG axis and the estrogen shield: what is happening across the 35-year reproductive era and what changes at perimenopause

Therefore, SIRT6 plays a key role in regulating glucose and lipid metabolism and signaling, particularly in DKD (Wang et al., 2023c)

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