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Importantly, resveratrol has been shown to modulate bone marrow-derived dendritic cells, subsequently affecting the secretion levels of IL-22 and IL-10, thereby influencing the progression of atherosclerosis (131)

In this context, a study on antibiotics for ME/CFS patients with high stool Streptococcus counts indicated that reducing these counts led to improved sleep [78]

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10.1016/j.bbadis.2020.165832 99 Twarda-ClapaA.OlczakA.BiakowskaA

While only few cases of hepatotoxicity, assessed using Roussel Uclaf Causality Assessment Method (RUCAM) method, from prolonged intake of piperine and curcumin have been reported, it would be reasonable to speculate that the suspected toxicity of Curcuma longa could be due to the concomitant presence of piperine itself

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