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Medication, such as non-steroidal anti-inflammatory drugs (NSAIDs), can be prescribed to reduce swelling and alleviate pain

Depression Vitamin B12 is necessary for the proper functioning of the brain

In the head-to-head SURMOUNT-5 trial (NEJM, 2025), tirzepatide produced 20.2% body weight loss vs 13.7% for semaglutide at 72 weeks, with similar side-effect profiles

An example of this is sudden infant death syndrome traced back to high body serum levels of thiamin

When oral B12 may be used Oral B12 may be appropriate for many people who need general supplementation or who have mild deficiency

Many providers choose 5 mg here because your established GLP-1 tolerance means 2.5 mg would likely feel like a notable step down in appetite suppression