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Vasodilators, such as prostaglandin I 2 (PGI 2 ), acting via G s -coupled (IP) receptor on VSMC, activate PKA and decrease intracellular Ca 2+ , leading to reduced MLC phosphorylation on Ser 19 [Figure 1,Table 1]

While BPC-157 appears safe based on available evidence, the lack of long-term human studies means unknown risks could exist

Peripherally, OXTR activation triggers smooth-muscle contraction most notably uterine contraction during labor and milk let-down during lactation [1]

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